"A Wonderfull Prognostication" (1591)

Npgrj_nbt_1260 1591..1597

N-glycosylation is critical to the function of monoclonal antibodies (mAbs) and distinguishes various systems used for their production. We expressed human mAbs in the small aquatic plant Lemna minor, which offers several advantages for manufacturing therapeutic proteins free of zoonotic pathogens1. Glycosylation of a mAb against human CD30 was optimized by co-expressing the heavy and light cha...

Dmd050005 1584..1591

Fibrinogen g-chain (dodecapeptide HHLGGAKQAGDV, H12)–coated, ADP-encapsulated liposomes [H12-(ADP)-liposomes] were developed as a synthetic platelet alternative that specifically accumulates at bleeding sites as the result of interactions with activated platelets via glycoprotein IIb/IIIa and augments platelet aggregation by releasing ADP. The aim of this study is to characterize the pharmacoki...

Prognostication: medicine's lost art.

Neurological prognostication after cardiac arrest

The care of the comatose cardiac arrest patient and his/her relatives in the ICU constitutes a major challenge for intensivists. Out-of-hospital cardiac arrest (OHCA) affects more than 275.000 Europeans yearly; survival rates are disturbingly low and have until recently remained unchanged [1]. During the last several years, significant efforts have been made to improve the quality of prehospita...

The fine art of prognostication

[1] Conraads et al. Combined endurance/resistance training reduces plasma TNFreceptor levels in patients with chronic heart failure and coronary artery disease. Eur Heart J, 2002; 23: 1854–1860. [2] Ferrara R, Mastrorilli F, Pasanisi G et al. Neurohormonal modulation in chronic heart failure. Eur Heart J Supplements 2002; 4 (Suppl D): D3–D11. [3] Cohn JN, Tognoni G for the Valsartan Heart Failu...